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US 2024/0376439 A1Published application
Freeze dried viral nanoparticle constructs
OwnerJonathan Pokorski, Nicole Steinmetz +1inventors
InventorsJonathan Pokorski, Nicole Steinmetz, Parker Lee
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Abstract
A method of producing plant virus-like particles includes freeze drying an aqueous solution of plant virus particles to produce a substantially RNA-free plant virus-like particles.
Claims20
A method of producing plant virus-like particles, the method comprising:
- freeze drying an aqueous solution of plant virus particles to produce a substantially RNA-free plant virus-like particles.
A method of producing e plant virus-like particles, the method comprising:
- freezing an aqueous solution of plant virus particles at a temperature and for an amount of time that allows the plant virus particles to eject the encapsulated genomic RNA while maintaining an intact capsid conformation;
- and
- sublimating the frozen aqueous solution of plant virus particles to remove water and RNA in the plant virus capsid.
A composition comprising a plurality of freeze dried, endoribonuclease treated cowpea mosaic virus-like particles.
Dependencies are inferred from the claim text.