Protease-activated polypeptides
AssigneeHoffmann-La Roche Inc.
InventorsSamuele CALABRO, Peter BRUENKER, Linda FAHRNI, Anne FREIMOSER-GRUNDSCHOBER, Martina GEIGER, Ralf HOSSE, Christian KLEIN, Ekkehard MOESSNER, Evelyn SAUER, Pablo UMAÑA, Inja WALDHAUER
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Abstract
The present invention generally relates to novel isolated polypeptides and immunoconjugates and their uses. The polypeptides and immunoconjugates comprise at least one protease recognitions sequence, which is a substrate for matriptase.
Claims23
An isolated polypeptide comprising a protease recognition site, wherein the protease recognition site is a substrate for matriptrase and comprises or consists of the sequence PQARK according to SEQ ID NO:
- 32 or HQARK according to SEQ ID NO:
- 33.
A therapeutic agent, comprising a protease recognition site, wherein the protease recognition site is PQARK according to SEQ ID NO:
- 32 or HQARK according to SEQ ID NO:
- 33.
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Dependencies are inferred from the claim text.