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AssigneeGrey Wolf Therapeutics Limited
InventorsMartin QUIBELL, Jason John SHIERS, John FEUTRILL
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The present invention relates to a compound of formula (I), or a pharmaceutically acceptable salt or hydrate thereof, Formula (I), wherein, the group X—Y is —NHSO2—; Z is a monocyclic or polycyclic cycloalkyl group or a monocyclic or polycyclic heterocycloalkyl group, each of which is optionally substituted by one or more groups selected from haloalkyl, alkyl, alkenyl, alkynyl and —(CR16R17)mR18, where m is 0 to 6; L is a direct bond or a group (CR14R15)n, where n is 1 or 2; R1 is H, CN, Cl or F or alkyl; R2 is selected from COOH and a tetrazolyl group; R3 is selected from H, halo, alkoxy and alkyl; R4 is selected from H and halo; R5 is selected from H, alkyl, haloalkyl, SO2-alkyl, Cl, alkoxy, OH, CN, hydroxyalkyl, alkylthio, heteroaryl, cycloalkyl, heterocycloalkyl and haloalkoxy; R6 is H; R7 is selected from H, CN, haloalkyl, halo, SO2-alkyl, SO2NR12R13, heteroaryl, CONR10R11 and alkyl, wherein said heteroaryl group is optionally substituted by one or more substituents selected from alkyl, halo, alkoxy, CN, haloalkyl and OH; R9 is selected from H, alkyl and halo; Rio, R1, R12 and R13 are each independently H or alkyl; R14 and R15 are each independently H, halo or alkyl; R16 and R17 are each independently H, halo, haloalkyl or alkyl; and each R18 is independently selected from OH, CN, alkoxy and halo. Further aspects of the invention relate to such compounds for use in the field of immune-oncology and related applications.
A compound of formula (I), or a pharmaceutically acceptable salt or hydrate thereof,
A compound according to any preceding claim wherein Z is a 3- to 7-membered monocyclic cycloalkyl or a 3- to 7-membered monocyclic heterocycloalkyl group, each of which is optionally substituted.
A compound according to any preceding claim wherein Z is a 4-membered monocyclic cycloalkyl or a 4-membered monocyclic heterocycloalkyl group, each of which is optionally substituted.
A compound according to any preceding claim wherein Z is a 4-membered monocyclic cycloalkyl group which is optionally substituted.
A compound according to any preceding claim wherein Z is selected from:
A compound according to any preceding claim wherein R2 is COOH.
A compound of formula according to any preceding claim wherein R4 is selected from H and F.
A compound according to any preceding claim wherein R5 is selected from alkyl, haloalkyl, SO2-alkyl, Cl, alkoxy, OH, CN, hydroxyalkyl, alkylthio, heteroaryl, cycloalkyl, heterocycloalkyl and haloalkoxy, and is more preferably selected from alkyl, alkoxy and cycloalkyl.
A compound according to any preceding claim wherein R5 is selected from OMe, OEt, Me, Et and cyclopropyl, and is more preferably selected from OMe, Et and cyclopropyl, and is even more preferably cyclopropyl.
A compound according to any preceding claim wherein R5 is cyclopropyl.
A compound according to any preceding claim wherein R7 is selected from H, CN, haloalkyl, Cl, F, SO2-alkyl, CONR10R11, heteroaryl and alkyl, wherein the heteroaryl group is selected from pyrazol-3-yl, pyrazol-4-yl, pyrazol-5-yl, isothiazol-3-yl, isothiazol-4-yl, isothiazol-5-yl, 1,2,4-triazol-5-yl, tetrazol-1-yl, tetrazol-5-yl, isoxazol-3-yl, isoxazol-4-yl and isoxazol-5-yl, each of which is optionally substituted by one or more substituents selected from alkyl, halo, alkoxy, CN, haloalkyl and OH.
A compound according to any preceding claim wherein R7 is CN.
A compound according to any preceding claim wherein R8 is selected from H and halo, more preferably, H, C and F.
A compound according to any preceding claim wherein R8 is Cl.
A compound according to any preceding claim wherein R9 is H, Me, F or C, more preferably, H.
A compound according to any preceding claim wherein R1 is H.
A compound according to any preceding claim wherein R1, R3, R4 and R9 are all H.
A compound according to any preceding claim which is selected from the following:
Dependencies are inferred from the claim text.