Mechanisms and predictors of adjuvanticity and antibody durability
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsBali Pulendran, Thomas Hagan, Mario Cortese, Sheng-Yang Wu
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Abstract
Methods are provided herein for vaccine development, characterization and validation. Using the response signatures disclosed herein, methods are provided for optimization, selection and benchmarking of vaccines, including adjuvants for vaccines. The methods include a prediction of response durability. e.g. the longevity of an antibody response, for a candidate vaccine or vaccine adjuvant; and assessment of similarity to a benchmark reference vaccine.
Claims21
A method for determining whether a candidate adjuvant provides for a core response substantially similar to a high performing reference adjuvant, the method comprising:
- administering a vaccine with the candidate adjuvant, to a mammal;
- determining an a core response signature from immune cells;
- and
- predicting whether the candidate adjuvant induces the core response by day 1 changes in expression.
A method is for predicting the durability of an immune response to a candidate vaccine, the method comprising:
- administering the candidate vaccine to a mammal;
- determining a signature response from a sample comprising immune cells in the mammal, and
- predicting durability of response from the signature response.
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Dependencies are inferred from the claim text.