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AssigneesStemrim Inc., Osaka University
InventorsKatsuto TAMAI, Takashi SHIMBO, Takehiko YAMAZAKI
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The present inventors identified many nuclear proteins contained in the extract of skin tissue by mass spectrometry, randomly selected multiple partial amino acid sequences of the nuclear proteins, chemically synthesized peptides consisting of the partial amino acid sequences, and examined their activity of mobilizing mesenchymal stem cells. As a result, it was found that these multiple peptides show the activity of mobilizing mesenchymal stem cells into peripheral blood, even though their amino acid sequences are completely different from each other. The inventors also found that fragment peptides of the nuclear proteins have therapeutic effects on diseases characterized by inflammation and abnormalities of the immune system (e.g., inflammatory bowel disease and psoriasis). Based on these findings, a new regenerative medicine technology that can overcome the problems of cell transplantation therapy is provided.
A method for treating a disease or pathological condition in a subject by mobilizing mesenchymal stem cells to peripheral blood, which comprises administering to the subject an effective amount of a nuclear protein or a fragment peptide thereof.
A method for treating a disease selected from inflammatory bowel disease or psoriasis in a subject, which comprises administering to the subject an effective amount of a nuclear protein or a fragment peptide thereof.
A fragment peptide of a nuclear protein selected from the following:
Dependencies are inferred from the claim text.