Amide compound and use thereof

A compound of formula (I), or a pharmaceutically acceptable salt, tautomer, mesomer, racemate, stereoisomer, metabolite, metabolic precursor, or prodrug thereof.

• wherein
• Ra is presented by the formula (II):
• X1 is N or CR1;
• X2 is N or CR2;
• X3 is N or CR3;
• X4 is CH2, O, S, NR4, C═O, or C═S;
• X1, X2, X3, and X4 are not N at the same time;
• X5 and X7 are each independently O or S;
• X6 is O, S, or X6 is absent;
• R1, R2, R3, and R4 are each independently selected from hydrogen, deuterium, C1-3 alkyl, C1-3 alkoxy, C3-6 cycloalkyl, 3- to 6-membered heterocycloalkyl, 4- to 7-membered aryl, 4- to 7-membered heteroaryl, hydroxyl, halogen, cyano, or —N(R5)(R6);
• R5 and R6 are each independently selected from hydrogen, C1-3 alkyl, C1-3 alkoxy, C3-6 cycloalkyl, 4- to 7-membered heterocycloalkyl, 4- to 7-membered heteroaryl, or R5 and R6 together with the nitrogen atom to which they are attached form a 3- to 6-membered mono saturated nitrogen-containing ring;
• R10 is hydrogen, deuterium, C1-3 alkyl, C1-3 alkoxy, hydroxyl, halogen, or cyano;
• m is 0, 1, 2 or 3;
• Rb is C1-12 alkyl, Si1-3 alkyl, C1-12 alkoxy, C2-12 alkenyl, C2-12 alkyne, C3-12 cycloalkyl, 3- to 12-membered heterocycloalkyl, 5- to 12-membered aryl, 5- to 12-membered heteroaryl, 6- to 12-membered dicyclic carbon ring, 6- to 12-membered partially unsaturated bicyclic carbon ring, 8- to 12-membered benzoheterocyclic, 6- to 12-membered bicyclic heteroaryl, 10- to 15-membered tricyclic carbon ring or 10- to 15-membered partially unsaturated tricyclic carbon ring, wherein the C1-12 alkyl, C1-12 alkoxy, C2-12 alkenyl, C2-12 alkyne, C3-12 cycloalkyl, 3- to 12-membered heterocycloalkyl, 5- to 12-membered aryl, 5- to 12-membered heteroaryl, 6- to 12-membered bicyclic carbon rings, 6- to 12-membered partially unsaturated bicyclic carbon rings, 6- to 12-membered bicyclic heteroaryl, 10- to 15-membered tricyclic carbon rings, and the 10- to 15-membered partially unsaturated tricyclic carbon rings, are optionally substituted with one or more R;
• X is methylene, each hydrogen on the methylene is optionally substituted with one or more deuterium or halogen;
• Q is a bond, —CR7═CR7—, —C≡C—, —C(R7)═N—, —N═C(R7)— or —N═N—;
• preferably, Q is —C≡C—;
• each R7 is independently selected from hydrogen, deuterium, C1-6 alkyl, C1-6 alkoxy, C3-9 cycloalkyl, 3- to 9-membered heterocycloalkyl, 5- to 9-membered aryl, 5- to 9-membered heteroaryl, hydroxyl, halogen, cyano, wherein the C1-6 alkyl, C1-6 alkoxy, C3-9 cycloalkyl, 3- to 9-membered heterocycloalkyl, 5- to 9-membered aryl, and 5- to 9-membered heteroaryl are optionally substituted with one or more R;
• each R is independently selected from deuterium, phosphonates, C1-6 alkyl, C1-6 alkoxy, Si1-6 alkoxy, C1-6 alkoxy carbonyl, —C(O)—C1-6 alkyl, —C(O)—C1-6 alkoxy, —O—C(O)—C1-6 alkyl, —O—C(O)-3- to 9-membered heterocycloalkyl, C3-9 cycloalkyl, 3- to 9-membered heterocycloalkyl, 5- to 9-membered aryl, 5- to 9-membered heteroaryl, carboxy, hydroxyl, halogen, cyano, amino, nitro, or —N(R8)(R9), wherein C1-6 alkyl, Si1-6 alkoxy, C(O)—C1-6 alkyl, —C(O)—C1-6 alkoxy, O—C(O)—C1-6 alkyl, —O—C(O)—C6-12 heterocycloalkyl, 5- to 9-membered aryl, and 3- to 9-membered heterocycloalkyl are optionally substituted with one or more halogen, carboxyl, nitro, amino, C1-6 alkyl, and 6-membered heterocycloalkyllor —O—C(O)—C1-6 alkyl;
• and H atoms on the phosphonate are optionally substituted with one or more R11;
• each R11 is independently selected from methyl or phenyl, or two R11 together with the atoms to which they are attached O and P form a dioxophosphate heterocyclic alkyl ring, wherein the dioxophosphate heterocyclic alkyl ring is optionally substituted with one or more methyl;
• R8 and R9 are each independently selected from hydrogen, C1-6 alkyl, C1-6 alkoxy, C3-9 cycloalkyl, 4- to 7-membered heterocycloalkyl or 4- to 7-membered heteroaryl, wherein the C1-6 alkyl is optionally substituted with one or more hydroxyl, halogen, cyano or C1-3 alkoxy;
• or R8 and R9 together with the nitrogen atom to which they are attached form 3- to 6-membered mono saturated nitrogen-containing ring;
• n is an integer from 0 to 5.