Solid state forms of daprodustat and process for their preparation
AssigneeReddy’s Laboratories Limited
InventorsBARLA RAJU, SHARMISTHA PAL, SRINIVAS ACHANTA, DEBJIT BASU, PAVANI SANKAR REDDY, ARUN AEDHUNURI, SRINIVASULU RANGINENI, NAGA SAI SWAROOP GANNAVARAPU
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Abstract
A crystalline form DP-9 of Daprodustat is provided, where an X-ray powder diffraction pattern of the crystalline form DP-9 shows one or more characteristic peaks at 6.4, 7.2, 7.5, 12.3, 15.1, 15.5, 16.6, 18.5, 19.3, 21.0, and 27.6±0.2 2θ.
Claims10
A crystalline form DP-9 of Daprodustat, wherein an X-ray powder diffraction pattern of the crystalline form DP-9 shows one or more characteristic peaks at 6.4, 7.2, 7.5, 12.3, 15.1, 15.5, 16.6, 18.5, 19.3, 21.0, and 27.6±0.2 2θ.
A process of preparing a crystalline form DP-9 of Daprodustat, the comprising:
- dissolving Daprodustat in polar aprotic solvent to obtain a reaction mixture;
- heating the reaction mixture to get a solution;
- optionally adding another organic solvent;
- isolating a solid obtained;
- drying in a suitable temperature;
- and
- optionally milling.
A process for preparing Daprodustat, the process comprising,
- converting compound 2 to compound 3 in presence of carbonyl reagent (C═O reagent) and amine reagent;
- and
- converting compound 3 to Daprodustat.
A process for preparing Daprodustat, the method comprising,
- converting compound 2 to compound 3 in presence of carbonyldiimidazole and Glycine methylester,
- converting compound 3 to Daprodustat.
Dependencies are inferred from the claim text.