Adipose tissue processing device
AssigneeDsm IP Assets B.V.
InventorsWilliam T. FISHER, Amit DEKA
Life of this patent
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Abstract
Disclosed herein are devices and methods for processing biologic tissues, such as adipose tissue or whole blood, via centrifugation, An annular cavity is present, typically at the widest interior point of a rotatable chamber. The device is operable such that a sample of biologic tissue present in the rotatable chamber can be stratified into at least two constituent layers as a function of the differing specific gravities of the constituents and at least a portion of one of the constituent layers captured in the annular cavity.
Claims20
A device for processing biologic tissue, the device comprising:
- a. a rotatable chamber arranged to rotate about an axis, the rotatable chamber at least partially defined by a first section and a second section, each of the first section and the second section comprising a base, an end, and a sidewall connecting the base and the end, the sidewall comprising at least one inclined surface such that each section decreases in interior width over at least a portion of the distance from its base to its end, the first section and second section positioned opposite one another such that the first section base and the second section base are positioned adjacent to one another, and
- b. a drive unit configured to rotate the rotatable chamber about the axis and produce a centrifugal field via rotation of the rotatable chamber about the axis:
- wherein at a first position the device comprises a passage defining the entrance to an annular cavity, the annular cavity being present i) in a sidewall of the first section or second section, or ii) between the first section and the second section, and wherein the device is configured such that upon operation at least a portion of a sample of biologic tissue present in the rotatable chamber is stratified into at least two constituent layers as a function of the differing specific gravities of the constituents of the sample of biologic tissue, and wherein at least a portion of one or more of the at least two constituent layers may enter the annular cavity.
A device for processing biologic tissue, the device comprising:
- a. a rotatable chamber arranged to rotate about an axis and comprising a sidewall connecting the ends of the chamber, wherein the interior of the rotatable chamber varies in width along at least a portion of the distance from a first end to the second end such that the widest point of the rotatable chamber is located between the first end and the second end, the rotatable chamber comprising an annular cavity proximate its widest point, and
- b. a drive unit configured to rotate the rotatable chamber about the axis and produce a centrifugal field via rotation of the rotatable chamber about the axis:
- wherein the device is configured such that upon operation at least a portion of a sample of biologic tissue present in the rotatable chamber is stratified into at least two constituent layers as a function of the differing specific gravities of the constituents of the sample of biologic tissue, and wherein at least a portion of one or more of the at least two constituent layers may enter the annular cavity.
A process for processing a sample of biologic tissue comprising the steps of:
- a placing a sample of biologic tissue at the center of a rotatable chamber, the rotatable chamber having two ends and comprising an annular cavity present between two ends of the rotatable chamber,
- b. rotating the rotatable chamber, thereby producing a centrifugal field,
- c. morselizing at least a portion of the biologic tissue by passing a quantity of the biologic tissue through a morselizing screen present within the rotatable chamber, thereby forming a morselized sample,
- d. stratifying the morselized sample into at least two constituents based on the specific gravity of the constituents, and
- e. depositing a constituent having the highest specific gravity into the annular cavity.
Dependencies are inferred from the claim text.