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US 2024/0366808 A1Published application
Method for preparing an [18f] radiolabelled compound with low water content during labelling step
AssigneeGe Healthcare Limited
InventorsTorgrim ENGELL, Graeme MCROBBIE, Alan CLARKE, Julian GRIGG, Imtiaz Ahmed KHAN, Kristine WIKENE, Jonathan Robert SHALES, Alexander JACKSON
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Abstract
The invention relates to a method of preparing an [18F] radio-labelled compound, wherein the water content is controlled. Controlling the water content and the origin of the water within the reaction process has a significant effect on both the yield and the purity of the product of the radio-labelling process.
Claims18
A method of preparing an [18F] radiolabelled compound, wherein the method comprises:
- (a) an initial drying step comprising evaporating water and acetonitrile from a solution comprising [18F] fluoride;
- (b) a further drying step (fluoride activation step) comprising azeotropic distillation of water from said solution comprising [18F] fluoride with acetonitrile;
- and
- (c) labelling a precursor compound with [18F] fluoride from the solution comprising [18F] fluoride yielded from step (b) to obtain an [18F] radiolabelled compound;
- wherein water content during labelling step (c) that originates from the solution comprising [18F] fluoride after drying step (b) is less than 500 ppm;
- and
- wherein the water content during labelling step (c) that originates from the precursor compound is no more than 2000 ppm.
4 more elements
Dependencies are inferred from the claim text.