Hyperpolarisation method and product
AssigneeCambridge Enterprise Limited
InventorsArnaud COMMENT, Adam GAUNT, Jennifer Sunari LEWIS, Irene MARCO-RIUS, Tian CHENG
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Abstract
In a method for preparing a hyperpolarised sample, for example for a magnetic resonance procedure, a starting solution comprising alpha-ketoglutaric acid and 13C-labelled molecules is frozen to form a frozen solution. The solution is irradiated with ultraviolet and/or visible radiation, to generate free radicals. The frozen solution is then hyperpolarised by applying a magnetic field to the solution while irradiating it with frequency-modulated microwave radiation.
Claims15
A method for preparing a hyperpolarised sample comprising the steps of:
- freezing a solution comprising alpha-ketoglutaric acid and 13C-labelled molecules to form a frozen solution;
- irradiating the frozen solution with ultraviolet and/or visible radiation;
- hyperpolarising the frozen solution by applying a magnetic field to the solution while irradiating the frozen solution with frequency-modulated microwave radiation.
A hyperpolarised sample for use in NMR, MRS or MRI containing alpha-KG at a concentration of less than 50 mM and containing succinic acid at a concentration of less than 20 mM.
Dependencies are inferred from the claim text.