Tissue catalyzed growth of polymer as epithelial linings for therapy
AssigneesMassachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.
InventorsRobert S. Langer, Carlo Giovanni Traverso, Junwei Li, Thomas Wang, Ameya R. Kirtane, Yunhua Shi
Life of this patent
Estimating the term…
Abstract
The present disclosure provides compositions, methods, and kits that enable the in situ growth of polymers on or within a subject. In some aspects, the monomer, dopamine, polymerizes in vivo to form a polymer on a tissue. In additional aspects, the compositions, methods, and kits are useful for treating or preventing a disease or disorder.
Claims26
1-112. (canceled)
A composition suitable for oral administration comprising dopamine and an oxygen source, wherein the oxygen source reacts with a catalyst in a small intestine of a subject to release oxygen from the oxygen source to polymerize the dopamine on the lumen of the small intestine.
114-115. (canceled)
118-121. (canceled)
123-124. (canceled)
132-148. (canceled)
(canceled)
Dependencies are inferred from the claim text.