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US 2024/0366674 A1Published application
Tumoricidal and antimicrobial compositions and methods
AssigneeImmunityBio, Inc.
InventorsHans G. Klingemann, Barry J. Simon
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Abstract
Provided herein are pharmaceutical compositions comprising tumoricidal and/or antimicrobial components isolated from the supernatant of NK-92 cell medium and methods of using the compositions for killing cancer cells.
Claims15
-10. (canceled)
A method of producing a cell-based product, comprising:
- growing a plurality of NK-92 cells in a culture medium comprising a cytokine;
- wherein the NK-92 cells are a subpopulation of wild type NK-92 cells or modified NK-92 cells;
- wherein the subpopulation of wild type NK-92 cells or modified NK-92 cells is grown under conditions and for a time sufficient to produce cytotoxic exosomes and/or microvesicles;
- and
- removing at least some of the culture medium containing the exosomes and/or microvesicles from the subpopulation of wild type NK-92 cells or modified NK-92 cells in the culture medium.
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Dependencies are inferred from the claim text.