Antibacterial porphyrin nanoparticles and methods for making and using the same

Abstract

Described herein are antibacterial nanoparticles composed of a porphyrin and a nitric oxide donor. In one aspect, the antibacterial nanoparticles are produced by the method comprising (a) admixing a porphyrin with glutathione or a pharmaceutically acceptable salt or ester thereof to produce a first compound and (b) reacting the first compound with a nitric oxide compound, wherein the nitric oxide compound forms a covalent bond with glutathione or the pharmaceutically acceptable salt or ester. The antibacterial nanoparticles are dynamic in their ability to specifically target pathogenic infections while remaining nontoxic towards mammalian cells and can also be used as medical device coatings to prevent infections as well as in treatment and management of diseases like cancer and autoimmune skin disorders.

Dependencies are inferred from the claim text.