Modulators of a potassium channel and of trpv1 channel and uses thereof

A compound represented by Formula I:

• wherein:
• A and B are each independently selected from an aryl and a heteroaryl;
• W is selected from —S—, —O—, —CR1(OH)—, —C(═O), and NRx, wherein said Rx forms a nitrogen-containing heterocyclic ring with one of the Ra substituents of ring A;
• n is an integer of from 1 to 5;
• m is an integer of from 0 to 4;
• Ra and Rb are each independently a substituent selected from alkyl, cycloalkyl, halo, haloalkyl, haloalkoxy, alkoxy, ether, aryl, heteroaryl, heteroalicyclic, aryloxy, hydroxy, amine, alkylamine, thiohydroxy, thioalkoxy, thioaryloxy, cyano, carboxylate, amide, carbamate, sulfonyl, and sulfonamide, or, alternatively, at least two of the Ra substituents form together an alicyclic or heterocyclic ring, at least one of the Ra substituents forms together with Rx, if present, said nitrogen-containing heterocyclic ring and/or at least two of the Rb substituents form together an alicyclic or heterocyclic ring, wherein when n is greater than 1, each Ra is the same or different substituent, and when m is greater than 1, each Rb is the same or different substituent;
• R1, if present, is hydrogen or alkyl;
• V is —(CR2R3)k-U;
• k is 0, 1 or 2;
• R2 and R3 are each independently hydrogen, alkyl, cycloalkyl and aryl;
• U is amide (—C(═O)—NR10—) or an isostere thereof;
• and
• Z is represented by Formula II:
• wherein:
• u and q are each independently an integer of from 0 to 4, provided that u+q is at least 2;
• X is selected from —O— and —NR9—, or is absent;
• Y is OR11;
• R5, R6, R7 and R8 are each independently selected from hydrogen, halo, alkyl, haloalkyl, cycloalkyl, heteroalicyclic, aryl, alkylamine, alkoxy, haloalkoxy, hydroxy, ether and aryloxy, or, alternatively, two of R5, R6, R7, R8 and R9 form together an alicyclic or heteroalicyclic ring;
• and
• R9, R10, R11, R12, R13 and R14 are each independently selected from hydrogen, alkyl, cycloalkyl, and aryl, or, alternatively, two of R5, R6, R7, R8, R9 and R11 or two of R5, R6, R7, R8, R9, R12 and R13 form together an alicyclic or heteroalicyclic ring,
• and wherein when W is —S—, —O—, —CR1(OH)—, or —C(═O), at least one of said Ra substituent(s) is selected from alkyl, haloalkyl, cycloalkyl and aryl and is at the ortho position with respect to said W;
• and
• when said Rx forms said nitrogen-containing heterocyclic ring with one of the Ra substituents of ring A, ring B is a heteroaryl.