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US 2024/0366503 A1Published application
Crosslinked hydrogels with enhanced radiopacity for medical applications
AssigneeBoston Scientific Scimed, Inc.
InventorYen-Hao Hsu
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AssigneeBoston Scientific Scimed, Inc.
InventorYen-Hao Hsu
Estimating the term…
In some aspects, the present disclosure pertains to a radiopaque, reactive polymer comprising one or more hydrophilic polymer segments having a plurality of hydrophilic polymer segment ends, a plurality of iodinated cyclic anhydride residues covalently linked to the plurality of hydrophilic polymer segment ends, and a plurality of reactive moieties covalently linked to the iodinated cyclic anhydride residues. In some aspects, the present disclosure pertains to a system for forming a hydrogel composition that comprises (a) a nucleophilic compound and (b) such a radiopaque, reactive polymer. In some aspects, the present disclosure pertains to a method of treatment comprising administering to a subject a mixture that comprises (a) a nucleophilic compound and (b) such a radiopaque, reactive polymer under conditions such that the nucleophilic compound and the radiopaque, reactive polymer crosslink after administration.
A radiopaque, reactive polymer comprising one or more hydrophilic polymer segments having a plurality of hydrophilic polymer segment ends, a plurality of iodinated cyclic anhydride residues covalently linked to the plurality of hydrophilic polymer segment ends, and a plurality of reactive moieties covalently linked to the iodinated cyclic anhydride residues.
A system for forming a hydrogel composition that comprises (a) a nucleophilic compound and (b) a radiopaque, reactive polymer comprising one or more hydrophilic polymer segments having a plurality of hydrophilic polymer segment ends, a plurality of iodinated cyclic anhydride residues covalently linked to the plurality of hydrophilic polymer segment ends, and a plurality of reactive moieties covalently linked to the iodinated cyclic anhydride residues, wherein the reactive moieties are electrophilic moieties.
A method of treatment comprising administering to a subject a mixture that comprises (a) a nucleophilic compound and (b) a radiopaque, reactive polymer comprising one or more hydrophilic polymer segments having a plurality of hydrophilic polymer segment ends, a plurality of iodinated cyclic anhydride residues covalently linked to the plurality of hydrophilic polymer segment ends, and a plurality of reactive moieties covalently linked to the iodinated cyclic anhydride residues, wherein the reactive moieties are electrophilic moieties, wherein the mixture is administered under conditions such that the nucleophilic compound and the radiopaque, reactive polymer crosslink after administration.
Dependencies are inferred from the claim text.