Electrospun PNIPAAm/PCL Fiber Mats for Aligned Cell Sheets
AssigneeBoard of Regents, The University of Texas System
InventorsJaneta Zoldan, Alicia Allen
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Abstract
The present invention provides compositions comprising aligned fibers of electrospun PNIPAAm and poly (ε-caprolactone) (PCL) (denoted PNIPAAm/PCL fibers). The PNIPAAm/PCL compositions enable enhanced growth and detachment of intact anisotropic cell sheets. The compositions do not require chemical modification or resource-intensive techniques, thus saving time and expense, and have the potential to generate tissue-specific, aligned cell sheets for transplant studies.
Claims16
1-22. (canceled)
A fiber mat, comprising:
- Poly(N-isopropylacrylamide) (PNIPAAm) and poly(caprolactone) (PCL), wherein the PNIPAAm content is at least 90%;
- and
- a cell sheet.
A method of making a fiber mat, comprising the step of electrospinning a solution comprising poly (N-isopropylacrylamide) (PNIPAAm) and poly(caprolactone) (PCL) having a PNIPAAm to PCL ratio of at least 90%.
Dependencies are inferred from the claim text.