Engineering method for mesenchymal stem cells based on polyvalent antibody and application thereof

Abstract

An antibody monomer, including an antibody, and a first DNA monomer or a second DNA monomer, where the antibody is an anti-vascular cell adhesion molecule 1 (antiVCAM1) antibody. Nucleotide sequences of the first and second DNA monomers respectively consist of SEQ ID NO:1 and SEQ ID NO:2. A kit including the antibody monomer and an initiator including a nucleotide sequence consisting of SEQ ID NO: 3 is provided. This application also provides a polyvalent antibody including a first antibody monomer and a second antibody monomer, where the first antibody monomer includes the first DNA monomer and the antiVCAM1 antibody, and the second antibody monomer includes the second DNA monomer and the antiVCAM1 antibody. This application further provides a mesenchymal stem cell modified with the antibody monomer or the polyvalent antibody, and an application thereof in the treatment of tissue damage.

Dependencies are inferred from the claim text.