N-substituted c6 cyclyl carboxamide compounds and uses thereof
AssigneeAlcon Inc.
InventorsHeeren M. Gordhan, Mitchell A. deLong, Jill M. Sturdivant, David Archer Ellis, Cynthia L. Lichorowic
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Abstract
Described herein are modified monoterpene TRPM8 activating compounds. In particular, provided herein are compounds that affect the function of ion channels in a cell, and are useful as therapeutic agents or with therapeutic agents. The compounds provided herein are useful in the treatment of a variety of diseases and conditions including inflammatory eye diseases such as uveitis, cardiovascular diseases, inflammatory diseases, and diseases characterized by abnormal growth, such as cancers.
Claims24
A compound, having a formula:
- or a pharmaceutically acceptable salt thereof,
- wherein
- J1 is C1-13H2-19N0-2O0-3S0-1B0-1F0-3Cl0-1 comprising 0 to 3 rings and a molecular weight of about 39.0 to about 220.3;
- J2 is
- wherein
- J5 is halo, C1-3 alkyl, C1-3 haloalkyl, OH, NH2, N(H)Ac, N(H)Boc, N(H)Fmoc, or N(H)Cbz;
- J6 is H;
- and
- J7 is H, propyl, ethyl-NH2, ethyl-OH, acetyl, propenyl, propenolyl, methyloxiranyl, or methylenecyclopropanyl;
- or J6 and J7 together form a C1-6 alkylenyl bridge;
- and
- J4 is H, C1-6 heteroalkyl, C6-12 aryl, or C(O)—(C1-3 alkylene)-(C2-3 heterocycloalkyl);
- or J1 and J4, together with the nitrogen to which they are attached, form an unsubstituted C2-8 heterocycloalkyl, or C2-8 heterocycloalkyl substituted with one or two groups independently selected from C1-6 alkyl or C1-6 haloalkyl, wherein hetero refers to one, two, or three of, independently, N, O, or S.
6-21. (canceled)
A compound, selected from:
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.