Multi-technology printing system

A method of LIFT-based bio-printing, comprising:

• introducing a quantity of a biological material into a reservoir comprising at least one opening;
• placing an acceptor substrate opposite to said opening;
• providing an energy source disposed to provide energy to said biological material;
• applying at least one pulse of energy from said energy source to said biological material, thereby providing local heating to said biological material sufficient to create a bubble within said biological material and thereby forcing a portion of said biological material from said reservoir via said opening onto said acceptor substrate;
• repeating the previous step until a bio-printed material of a predetermined structure and shape is obtained;
• wherein at least one optical fiber and/or at least one fiber bundle are in communication with said energy source, such that said energy source is configured to emit energy into said optical fiber or said fiber bundle and to deliver said energy to an area to which said biologically active substance is to be deposited by said LIFT process, so as to facilitate in-situ LIFT performed inside the body during a procedure such that said biologically active substance is disposed within or onto said area being the body of a patient in need thereof.