Derivatives of korormicin useful as antibiotics
AssigneeViotika Life Sciences
InventorsPavel Dibrov, Elena Dibrov, Grant Pierce
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Abstract
An antibiotic compound of formula (I): or a salt or stereoisomer thereof; wherein R1-R3 and R5-R6 are independently selected from H or a C1-C5 alkyl group or a C1-C5 substituted alkyl group; R4 is a C1-C5 alkyl group or a C1-C5 substituted alkyl group; X1-X2 are independently selected from the group consisting of ═O, H, and OH; Y is an acyclic hydrocarbon chain of 2 to 20 carbon atoms; and Z is CH3. Also disclosed are methods of treating a bacterial disease including administering an effective amount of the compound to a subject in need thereof, wherein the bacterial disease is caused by a gram-negative bacteria.
Claims21
An antibiotic compound of formula (I):
- or a salt or stereoisomer thereof;
- wherein R1-R3 and R5-R6 are independently selected from H or a C1-C5 alkyl group or a C1-C5 substituted alkyl group;
- R4 is a C1-C5 alkyl group or a C1-C5 substituted alkyl group;
- X1-X2 are independently selected from the group consisting of ═O, H, and OH;
- Y is an acyclic hydrocarbon chain of 2 to 20 carbon atoms;
- and
- Z is CH3.
Dependencies are inferred from the claim text.