Novel cathepsin inhibitors
AssigneeEcole Polytechnique Federale De Lausanne (Epfl)
InventorsElisa Oricchio, Aaron Petruzzella, Bruno Correia
Life of this patent
Estimating the term…
Abstract
The present invention relates to a cathepsin inhibitor comprising or consisting of Formula (I) (X1)(X2)(X3)(X4)(Y)(X5)(X6)(X7) Formula (I) wherein (X1) is an amino acid selected from K, L, F and M; (X2) is an amino acid selected from L, A, D, E, F, G, H, I, K, M, N, S, W, Y, Q and R; (X3) is an amino acid selected from R, A and L; (X4) is an amino acid selected from M, I, K, V and Y; (X5) is an amino acid selected from P, A, I, L, V, W and Y; (X6) is an amino acid selected from K, A, E, F, G, I, L, M, N, Q, S, T, V, W, Y and Q; (X7) is an amino acid selected from D, A, E, F, G, I, L, M, N, P, T, V, W, Y, Q and R; and (Y) is a Michael acceptor.
Claims15
A cathepsin inhibitor comprising or consisting of Formula (I)
- (X1)(X2)(X3)(X4)(Y)(X5)(X6)(X7) Formula (I)
- wherein
- (X1) is an amino acid selected from K, L, F and M;
- (X2) is an amino acid selected from L, A, D, E, F, G, H, I, K, M, N, S, W, Y, Q and R;
- (X3) is an amino acid selected from R, A and L;
- (X4) is an amino acid selected from M, I, K, V and Y;
- (X5) is an amino acid selected from P, A, I, L, V, W and Y;
- (X6) is an amino acid selected from K, A, E, F, G, I, L, M, N, Q, S, T, V, W, Y and Q;
- (X7) is an amino acid selected from D, A, E, F, G, I, L, M, N, P, T, V, W, Y, Q and R;
- and
- (Y) is a Michael acceptor.
Dependencies are inferred from the claim text.