Crystal form of ripk1 inhibitor, acid salt thereof, and crystal form of acid salt thereof
AssigneesGenfleet Therapeutics (Shanghai) Inc., Zhejiang Genfleet Therapeutics Co., Ltd.
InventorsFusheng ZHOU, Yuanzhi TAO, Jinzhu ZHAO, Jiong LAN
Life of this patent
Estimating the term…
Abstract
Disclosed are a crystal form of a RIPK1 inhibitor, an acid salt thereof, and a crystal form of an acid salt thereof. The crystal form of the RIPK1 inhibitor, the acid salt thereof, and the crystal form of the acid salt thereof have advantages of good stability and low hygroscopicity, and same have good pharmaceutical prospects.
Claims20
A crystal form of a compound of formula I, wherein the crystal form of the compound of formula I is a crystal form A of the compound of formula I, a crystal form B of the compound of formula I, or a crystal form C of the compound of formula I;
- the crystal form A of the compound of formula I has an X-ray powder diffraction pattern expressed at a 2θ angle comprising diffraction peaks at the following 2θ angles:
- 10.94±0.2°, 16.43±0.2°, 19.12±0.2°, and 19.81±0.2°;
- the crystal form B of the compound of formula I has an X-ray powder diffraction pattern expressed at a 2θ angle comprising diffraction peaks at the following 2θ angles:
- 27.64±0.2°, 24.48±0.2°, 3.76±0.2°, and 19.30±0.2°;
- the crystal form C of the compound of formula I has an X-ray powder diffraction pattern expressed at a 2θ angle comprising diffraction peaks at the following 2θ angles:
- 19.55±0.2°, 29.51±0.2°, 19.99±0.2°, and 20.26±0.2°.
A pharmaceutically acceptable salt of a compound of formula I, wherein the pharmaceutically acceptable salt is a salt formed by the compound of formula I and an acid;
- the acid is an inorganic acid or an organic acid;
A crystal form of a pharmaceutically acceptable salt of a compound of formula I, wherein the crystal form of the pharmaceutically acceptable salt of the compound of formula I is a crystal form A of a hydrochloride salt of the compound of formula I, a crystal form A of a citrate salt of the compound of formula I, a crystal form A of a maleate salt of the compound of formula I, a crystal form A of a fumarate salt of the compound of formula I, a crystal form A of a methanesulfonate salt of the compound of formula I, a crystal form B of a methanesulfonate salt of the compound of formula I, a crystal form C of a methanesulfonate salt of the compound of formula I, a crystal form A of a p-toluenesulfonate salt of the compound of formula I, a crystal form A of a cyclamate salt of the compound of formula I, a crystal form A of a sulfate salt of the compound of formula I, a crystal form D of a sulfate salt of the compound of formula I, a crystal form B of a sulfate salt of the compound of formula I, a crystal form C of a sulfate salt of the compound of formula I, a crystal form E of a sulfate salt of the compound of formula I, or a crystal form F of a sulfate of the compound of formula I;
- the crystal form A of the hydrochloride salt of the compound of formula I has an X-ray powder diffraction pattern expressed at a 2θ angle comprising diffraction peaks at the following 2θ angles:
- 8.83±0.2°, 13.24±0.2°, 24.25±0.2°, and 18.31±0.2°;
- the crystal form A of the citrate salt of the compound of formula I has an X-ray powder diffraction pattern expressed at a 2θ angle comprising diffraction peaks at the following 2θ angles:
- 17.87±0.2°, 14.97±0.2°, 17.45±0.2°, and 17.01±0.2°;
- the crystal form A of the maleate salt of the compound of formula I has an X-ray powder diffraction pattern expressed at a 2θ angle comprising diffraction peaks at the following 2θ angles:
- 16.47±0.2°, 4.58±0.2°, 10.97±0.2°, and 22.91±0.2°;
- the crystal form A of the fumarate salt of the compound of formula I has an X-ray powder diffraction pattern expressed at a 2θ angle comprising diffraction peaks at the following 2θ angles:
- 28.83±0.2°, 5.03±0.2°, 16.15±0.2°, and 13.11±0.2°;
- the crystal form A of the methanesulfonate salt of the compound of formula I has an X-ray powder diffraction pattern expressed at a 2θ angle comprising diffraction peaks at the following 2θ angles:
- 5.76±0.2°, 14.75±0.2°, 5.11±0.2°, and 17.54±0.2°;
- the crystal form B of the methanesulfonate salt of the compound of formula I has an X-ray powder diffraction pattern expressed at a 2θ angle comprising diffraction peaks at the following 2θ angles:
- 18.83±0.2°, 16.51±0.2°, 25.51±0.2°, and 10.98±0.2°;
- the crystal form C of the methanesulfonate salt of the compound of formula I has an X-ray powder diffraction pattern expressed at a 2θ angle comprising diffraction peaks at the following 2θ angles:
- 19.57±0.2°, 19.98±0.2°, 16.50±0.2°, and 18.20±0.2°;
- the crystal form A of the p-toluenesulfonate salt of the compound of formula I has an X-ray powder diffraction pattern expressed at a 2θ angle comprising diffraction peaks at the following 2θ angles:
- 5.80±0.2°, 19.70±0.2°, 22.36±0.2°, and 11.57±0.2°;
- the crystal form A of the cyclamate salt of the compound of formula I has an X-ray powder diffraction pattern expressed at a 2θ angle comprising diffraction peaks at the following 2θ angles:
- 6.41±0.2°, 16.47±0.2°, 18.57±0.2°, and 10.95±0.2°;
- the crystal form A of the sulfate salt of the compound of formula I has an X-ray powder diffraction pattern expressed at a 2θ angle comprising diffraction peaks at the following 2θ angles:
- 14.60±0.2°, 11.67±0.2°, 21.09±0.2°, and 13.32±0.2°;
- the crystal form D of the sulfate salt of the compound of formula I has an X-ray powder diffraction pattern expressed at a 2θ angle comprising diffraction peaks at the following 2θ angles:
- 14.60±0.2°, 25.31±0.2°, 19.85±0.2°, and 20.07±0.2°;
- the crystal form I of the sulfate salt of the compound of formula I has an X-ray powder diffraction pattern expressed at a 2θ angle comprising diffraction peaks at the following 2θ angles:
- 12.92±0.2°, 26.90±0.2°, 15.86±0.2°, and 23.02±0.2°;
- the crystal form B of the sulfate salt of the compound of formula I has an X-ray powder diffraction pattern expressed at a 2θ angle comprising diffraction peaks at the following 2θ angles:
- 25.15±0.2°, 18.71±0.2°, 3.13±0.2°, and 23.28±0.2°;
- the crystal form C of the sulfate salt of the compound of formula I has an X-ray powder diffraction pattern expressed at a 2θ angle comprising diffraction peaks at the following 2θ angles:
- 5.55±0.2°, 14.72±0.2°, 16.75±0.2°, and 27.35±0.2°;
- the crystal form E of the sulfate salt of the compound of formula I has an X-ray powder diffraction pattern expressed at a 2θ angle comprising diffraction peaks at the following 2θ angles:
- 16.39±0.2°, 12.75±0.2°, 14.32±0.2°, and 20.28±0.2°;
- the crystal form F of the sulfate salt of the compound of formula I has an X-ray powder diffraction pattern expressed at a 2θ angle comprising diffraction peaks at the following 2θ angles:
- 24.91±0.2°, 20.60±0.2°, 27.62±0.2°, and 16.04±0.2°.
Dependencies are inferred from the claim text.