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AssigneeUniversity of Hyderabad
InventorsSatyajit Mukhopadhyay, Anand Kumar Kondapi, Ritika Das, Miss Hema
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The present invention relates to an anti-HIV recombinant HIV-1 derived Topoisomerase IIβ kinase. It inhibits HIV-1 replication by blocking viral entry. Its recognition by envelope antibodies ID6 and 4G10 makes it a justifiable immunogen for use as vaccine candidate in form of protein, mRNA and DNA vaccine against HIV infection. Thus, the protein, mRNA and DNA of immunogenic recombinant HIV-1 derived Topoisomerase IIβ kinase and derived peptides with and without spacers can be used as a HIV vaccine. FIG. 1, FIG. 2, FIG. 3, FIG. 4, FIG. 5, FIG. 6, FIG. 7, FIG. 7, FIG. 8, FIG. 9, FIG. 10, FIG. 11, FIG. 12, FIG. 13, FIG. 14, FIG. 15, FIG. 16.
A protein, mRNA and DNA of immunogenic recombinant HIV-derived Topoisomerase II beta kinase as an immunogen for HIV vaccine, wherein the Nucleotide sequence is given by:
Dependencies are inferred from the claim text.