Mesenchymal stem cell line
AssigneeUniversitäT Basel
InventorsSebastien PIGEOT, Ivan MARTIN, Paul BOURGINE
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Abstract
A mesenchymal stem/stromal (MSC) cell line, in particular a human mesenchymal stem cell (hMSC), capable of chondrogenic differentiation when cultured in a chondrogenic medium, comprising a first transgene comprising a first nucleic acid sequence encoding for a preferably mammalian immortalizing enzyme under control of a first promoter sequence operable in said mesenchymal cell and a second transgene comprising a second nucleic acid sequence encoding a preferably mammalian bone morphogenic protein under control of a second promoter sequence operable in said mesenchymal cell.
Claims14
A mesenchymal stem/stromal (MSC) cell line, in particular a human mesenchymal stem cell (hMSC), capable of chondrogenic differentiation when cultured in a chondrogenic medium, comprising
- a. a first transgene comprising a first nucleic acid sequence encoding for a preferably mammalian immortalizing enzyme under control of a first promoter sequence operable in said mesenchymal cell
- b. a second transgene comprising a second nucleic acid sequence encoding a preferably mammalian bone morphogenic protein under control of a second promoter sequence operable in said mesenchymal cell,
- c. optionally not comprising a third transgene encoding for a third nucleic acid sequence encoding a protein capable of triggering apoptosis in said mesenchymal stem cell when said cell is exposed to a triggering agent.
Dependencies are inferred from the claim text.