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US 2024/0343841 A1Published application
Enzyme-assisted atrp procedures
AssigneeCarnegie Mellon University
InventorsKrzysztof Matyjaszewski, Alan Enciso Barros, Liye Fu, Alan J. Russell
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Abstract
Materials and methods for conducting an atom transfer radical polymerization in the presence of oxygen by interlocking enzymatic activities are provided herein.
Claims23
A method for polymerizing free radically copolymerizable monomers, comprising combining:
- (a) a deoxygenated polymerization medium comprising (i) a transition metal catalyst or metal-free organic complex that can participate in a redox reaction, and (ii) an initiator comprising one or more redox transferable atoms or groups;
- (b) an oxygen scavenger;
- and
- (c) a reactive oxygen species (ROS) scavenger.
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An oxygen-driven ATRP method, wherein the method comprises combining:
- (a) a deoxygenated polymerization medium comprising (i) copper at a concentration less than 1500 ppm, wherein the copper is capable of participating in a redox reaction, and (ii) a halogen-containing initiator comprising one or more redox transferable atoms or groups;
- (b) an oxygen scavenger comprising glucose and GOx;
- and
- (c) a ROS scavenger comprising a pyruvate, horseradish peroxidase, an α-keto-acid, a catalase, or a catalase-like enzyme,
- wherein the concentrations of the oxygen scavenger and the ROS scavenger are sufficient to provide a continuous source of radicals for controlled polymerization from the halogen-containing initiator.
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Dependencies are inferred from the claim text.