Gas Exchange Composite Membranes and Methods of Use Thereof

A blood oxygenation device comprising:

• 1) a blood channel comprising a first inlet at a first end and a first outlet at a second end opposite the first end, wherein the blood channel is configured to pass a flow of blood from the first inlet to the first outlet;
• 2) a first gas channel configured to pass a flow of gas;
• and
• 3) a first gas exchange composite membrane,
• wherein the first composite membrane is disposed between the blood channel and the first gas channel in a manner sufficient to provide a gas permeable barrier between the blood channel and the first gas channel;
• wherein the first gas exchange composite membrane comprises
• i) a non-porous, gas-permeable, polymeric membrane defining a first surface and a second surface opposite the first surface;
• and
• ii) a non-compliant, microporous membrane defining a third surface and a fourth surface opposite the third surface, wherein
• the microporous membrane comprises one or more gas diffusion windows, each comprising a network of struts defining walls of a plurality of micropores, each micropore extending from the third surface to the fourth surface;
• and
• the third surface is attached to the second surface,
• wherein the first surface of the polymeric membrane provides an antithrombotic surface for gas exchange over the one or more gas diffusion windows, between blood flowing along the first surface and a gas at the second surface.