Medical devices including therapeutic coatings for local delivery of a direct anticoagulant
AssigneeBoston Scientific Scimed, Inc.
InventorsThomas John Herbst, Edward Kopesky, Steven L. Kangas, Hongxia Zeng, Aaron Cooper Foss
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Abstract
A medical device may be coated with a therapeutic composition that includes a direct oral anticoagulant. An illustrative drug coating composition may comprise an excipient including polylactic acid (PLA), poly(lactic-co-glycolic acid) (PLGA), or poly(vinylidene fluoride)-co-hexafluoropropylene (PVDF-HFP) and a direct oral anticoagulant (DOAC). The illustrative drug coating may be applied to an outer surface of a medical device.
Claims20
A balloon catheter, comprising:
- an elongated shaft;
- an inflatable balloon coupled to a distal portion of the elongated shaft;
- a drug coating composition disposed on an outer surface of the inflatable balloon, the drug coating composition comprising:
- an excipient;
- and
- a direct oral anticoagulant (DOAC).
A stent, comprising:
- an elongated tubular body having a strut framework;
- a drug coating composition disposed on an outer surface of the strut framework, the drug coating composition comprising:
- an excipient;
- and
- a direct oral anticoagulant (DOAC).
A method for manufacturing a drug coating composition, the method comprising:
- dissolving polylactic acid (PLA) or poly(lactic-co-glycolic acid) (PLGA) and rivaroxaban in a mixture of dichloromethane and dimethylformamide to form a first solution;
- adding the first solution to aqueous poly (vinyl acid) PVA while mixing to form a bead solution;
- filtering the bead solution to collect a plurality of microspheres;
- and
- drying the plurality of microspheres.
Dependencies are inferred from the claim text.