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US 2024/0337669 A1Published application
Reporter labeled annular clot system for diagnosis and research
AssigneeIndiana University Research and Technology Corporation
InventorsNathan Joseph Alves, Ziqian Zeng
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Abstract
Disclosed are compositions and methods of a microplate-based assay related to the field of thrombosis diagnosis, therapeutic screening, and drug development platforms.
Claims31
A labeled fibrin clot comprising:
- unlabeled fibrinogen and labeled fibrinogen at a ratio of unlabeled fibrinogen:labeled fibrinogen ranging from 0:1 to about 1:0, wherein the labeled fibrinogen comprises from 1 to 34-labels per fibrinogen;
- and a preformed clot-free detection path in the labeled fibrin clot.
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A method of analyzing fibrin clot lysis, the method comprising:
- contacting a thrombolytic agent with a labeled fibrin clot, wherein the labeled fibrin clot comprises
- a ratio of unlabeled fibrinogen:labeled fibrinogen ranging from 0:1 to about 50:1, wherein the labeled fibrinogen comprises from 1 to 34-labels per fibrinogen, and a preformed clot-free detection path;
- and
- analyzing the labeled fibrin clot.
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Dependencies are inferred from the claim text.