Anti-fungals compounds targeting the synthesis of fungal sphingolipids

A compound having the structure:

• wherein
• R3, R4, R5, R6, and R7 are each independently, H, halogen, —CN, —CF3, —OCF3, —NO2, alkyl, alkenyl, alkynyl, aryl, heteroaryl, heterocycle, —OH, —OAc, —OR13, —COR13, —CH2OR13, —SH, —SR13, —SO2R13, —NH2, —NHR13, —NR14R15, —NHCOR12, or —CONR14R15;
• R9, R10, R11, and R12 are each independently, H, —CN, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, —OAc, —OR13, —COR13, —SH, —SR13, —SO2R13, —NH2, —NHR13, —NR14R15, —NHCOR12, or —CONR14R15;
• wherein each occurrence of R13 is independently alkyl, alkenyl, alkynyl, aryl, or heteroaryl,
• wherein each occurrence of R14 is independently —H, alkyl, alkenyl, alkynyl, aryl, or heteroaryl,
• wherein each occurrence of R15 is independently —H, alkyl, alkenyl, alkynyl, aryl, or heteroaryl,
• wherein when R14 is methyl, R15 is not methyl;
• wherein at least one of R9, R10, R11, and R12 is not H;
• wherein at least one of R3, R4, R5, R6, and R7 is not H;
• wherein when one of R9, R10, R11, and R12 is —OR13, R3, R4, R5, R6, and R7 are not halogen or alkyl.