Cell populations in the anorectal transition zone with tissue regenerative capacity, and methods for isolation and use thereof

Abstract

Provided herein are compositions of anorectal transition zone stem cells, including multipotent and progenitor cells, to treat anal fistulas, for example, refractory complex perianal fistulas associated with Crohn's disease or of unknown aetiology. Also provided are pharmaceutical compositions of the anorectal transition zone stem cells, including multipotent and progenitor cells, in a pharmaceutically acceptable carrier.

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