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US 2024/0329031 A1Published application
Chemopredictive assay for recurrent chemotherapy
AssigneeOroc
InventorSaubhik SENGUPTA
Life of this patent
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Abstract
A chemopredictive assay, including culturing cancer cells of interest; exposing the cancer cultures to several chemotherapeutic agents; identifying the most effective chemotherapeutic agent; culturing surviving cancer cells to prepare second cultures; exposing the second cultures to several chemotherapeutic agents; and identifying the most effective chemotherapeutic agent for treating recurrent cancer.
Claims2
A method of screening chemotherapeutics for second-line chemotherapy, comprising:
- culturing cancer cells of interest to prepare plural first cultures;
- exposing each of the first cultures to one of a plurality of first chemotherapeutic agents;
- identifying a most effective member of the plurality of first chemotherapeutic agents;
- culturing cancer cells that survived exposure to the most effective first chemotherapeutic agent to prepare plural second cultures;
- exposing each of the second cultures of cancer cells to one of a plurality of second chemotherapeutic agents;
- and
- identifying a most effective member of the plurality of second chemotherapeutic agents.
4 more elements
A method of screening chemotherapeutics for second-line chemotherapy, comprising:
- preparing plural substrates, each substrate including a layer of normal cells on an organic matrix;
- culturing cancer cells of interest on the prepared substrates to prepare plural first cultures;
- and
- exposing each of the first cultures to one of a plurality of first chemotherapeutic agents.
1 more element
Dependencies are inferred from the claim text.