Macrocyclic peptidomimetic protease inhibitor and use thereof

A compound, being a compound shown in formula (I) or a stereoisomer, a tautomer, a nitrogen oxide, a solvate, a metabolite, a pharmaceutically acceptable salt, or a prodrug of the compound shown in formula (I),

• L1 being a linker;
• L2 being —(CH2)mCONR1— or
• being C or N;
• R1 being H, F, Cl, Br, CN, NO2, —ORb, —NRcRd, or C1-6 alkyl;
• R2a and R2b being each independently H, —C(═O)Ra, —C(═O)ORb, —S(═O)2Rb, —C(═O)NRcRd, —NC(═O)RcRd, —ORb, —NRcRd, RbO—C1-4 alkylene, RdRcN—C1-4 alkylene, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-8 cycloalkyl, C3-8 cycloalkyl-C1-4 alkylene, heterocyclyl including 3-12 atoms, (heterocyclyl including 3-12 atoms)-C1-4 alkylene, C6-10 aryl, C6-10 aryl-C1-4 alkylene, heteroaryl including 5-10 atoms, or (heteroaryl including 5-10 atoms)-C1-4 alkylene, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-8 cycloalkyl, C3-8 cycloalkyl-C1-4 alkylene, heterocyclyl including 3-12 atoms, (heterocyclyl including 3-12 atoms)-C1-4 alkylene, C6-10 aryl, C6-10 aryl-C1-4 alkylene, heteroaryl including 5-10 atoms, and (heteroaryl including 5-10 atoms)-C1-4 alkylene being each independently unsubstituted or substituted with one, two, three, or four substituents, the substituent being independently F, Cl, Br, CN, ═O, —ORb, —NRcRd, C1-6 alkyl, C1-6 haloalkyl, RbO—C1-4 alkylene, or RdRcN—C1-4 alkylene, and R2a and R2b being not all H;
• ring A being optionally heterocyclyl including 3-10 atoms or heteroaryl including 5-10 atoms that is substituted with one or more R′;
• Z being cyano, aziridine, epoxypropane, trifluoromethyl ketone, aldehyde, —CH(O(C═O)R3)SO3Na, —CH(O(C═O)OR3)SO3Na, —CH(O(C═O)NHR3)SO3Na, —(C═O)(C═O)NHR3, —(C═O)(P═O)(OR3), —(C═O)COOR3, acetoxymethyl ketone, Michael receptor, or substituted or unsubstituted heterocyclyl including 3-6 atoms or heteroaryl including 5-10 atoms, R3 being H, F, Cl, Br, CN, NO2, —ORb, —NRcRd, —S(═O)2Rb, C1-6 alkyl, C1-6 haloalkyl, C3-8 cycloalkyl, C3-8 cycloalkenyl, C3-8 cycloalkyl-C1-4 alkylene, heterocyclyl including 3-12 atoms, (heterocyclyl including 3-12 atoms)-C1-4 alkylene, C6-10 aryl, C6-10 aryl-C1-4 alkylene, heteroaryl including 5-10 atoms, or (heteroaryl including 5-10 atoms)-C14 alkylene;
• m being an integer between 1 and 6;
• n being 1 or 2;
• k being 0 or 1;
• R′ being independently H, F, Cl, Br, CN, NO2, ═O, —ORb, —NRcRd, —S(═O)2Rb, C1-6 alkyl, C1-6 haloalkyl, C3-8 cycloalkyl, C3-8 cycloalkenyl, heterocyclyl including 3-12 atoms, C6-10 aryl, or heteroaryl including 5-10 atoms, C3-8 cycloalkyl, heterocyclyl including 3-12 atoms, C6-10 aryl, or heteroaryl including 5-10 atoms being independently unsubstituted or substituted with one, two, three, or four substituents, and the substituent being independently F, Cl, Br, CN, ═O, —ORb, —NRcRd, C1-6 alkyl, C1-6 haloalkyl, RbO—C1-4 alkylene, or RdRcN—C1-4 alkylene;
• and
• Ra, Rb, Rc, and Rd being each independently H, C1-6 alkyl, C1-6 haloalkyl, heterocyclyl including 3-6 atoms, C6-10 aryl, heteroaryl including 5-10 atoms, or heterocycle including 3-6 atoms that is formed by Rc, Rd, and nitrogen atoms linked to Rc and Rd, C1-6 alkyl, heterocycle including 3-6 atoms, C6-10 aryl, and heteroaryl including 5-10 atoms being each independently unsubstituted or substituted with one, two, three, or four substituents, and the substituent being independently F, Cl, CN, OH, NH2, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy, or C1-6 alkylamino.