Pharmacological agents for preventing and treating cataracts and presbyopia eye diseases
AssigneePlex Pharmaceuticals, Inc.
InventorsSantosh C. SINHA, Sridhar Govinda PRASAD
Life of this patent
Estimating the term…
Abstract
Methods of treating presbyopia or cataract in a subject in need thereof are provided. The methods require administering to the subject an effective amount of a composition comprising a compound that inhibits the formation or dissolves high molecular weight aggregates of human α-A-crystallin. Compositions containing certain compounds are believed to be also effective in the treatment of transthyretin (TTR)-associated amyloidosis, Prion, Creutzfeldt-Jakob, Gerstmann-Sträussler-Scheinker disease and Ankyloblepharon-ectodermal dysplasia-cleft lip/palate syndrome.
Claims12
A compound, where in the compound is:
- or a solvate or a pharmaceutically acceptable salt thereof,
- wherein,
- R1 and R2 are the same or different, and each of R1 and R2 is independently selected from the group consisting of:
- hydrogen, R4C═O,
- R3a, R3b, R3c, and R3d are each the same or different, and each independently are selected from the group consisting of:
- hydrogen, branched or linear (C1-C6)alkyl, halo(C1-C6)alkyl, (C3-C6)cycloalkyl, halo(C3-C6)cycloalkyl, and hydroxyl;
- R4 is selected from the group consisting of:
- branched or linear (C1-C6)alkyl;
- halo(C1-C6)alkyl;
- (C3-C6)cycloalkyl;
- halo(C3-C6)cycloalkyl;
- aryl;
- haloaryl;
- and
- R5a and R5b are each the same or different, and independently a branched or linear (C1-C6)alkyl,
- R6 is branched or linear (C1-C6)alkyl, aryl, or a polyethylene glycol group or
- wherein q is 1 to 10;
- p is a number from 0 to 10,
- n is a number from 0 to 10, and
- X is a C or O;
A compound of formula (Ia):
- or a solvate or a pharmaceutically acceptable salt thereof;
- a compound of formula (Ib):
- or a solvate or a pharmaceutically acceptable salt thereof;
- a compound of formula (Ic):
- or a solvate or a pharmaceutically acceptable salt thereof;
- a compound of formula (Id);
- or a solvate or a pharmaceutically acceptable salt thereof;
- a compound of formula (Ie):
- or a solvate or a pharmaceutically acceptable salt thereof;
- or
- a compound of formula (If):
- or a solvate or a pharmaceutically acceptable salt thereof.
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A compound selected from:
- or a solvate or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.