Multi-target inhibitor targeting hdac and nad synthesis and use of multi-target inhibitor

An HDAC compound with multi-target inhibitory activity and a pharmaceutically acceptable salt, hydrate, deuterate, isomer or prodrug thereof, wherein the multi-target HDAC compound has a general formula I,

• Ring E-B-L-C(O)—(NH)r-R (General formula I)
• wherein, ring E is selected from
• r is equal to 1 and 2, R is selected from R1, and
• and the R1 is selected from H, C1-4 alkyl, C3-5 cycloalkyl or C1-2 alkyl substituted C3-5 cycloalkyl;
• ring A is selected from one or more substituted or unsubstituted 5-membered aromatic or heteroaromatic rings, the heteroaromatic ring contains 1 to 2 heteroatoms of N, O, or S;
• the substituents are H, halogen, C1-2 alkyl, halomethyl, OH, OCH3, O(CH2)nCH3, cyclopropyloxy, OC(CH3)3, OCH(CH3)2, NH2, N(CH3)2, NH(CH2)nCH3, CN, N3, etc., wherein n is from 0 to 9;
• X1 is selected from CR4 or N;
• X2 is selected from CR5 or N;
• X3 is selected from CR6 or N;
• X4 is selected from CR7 or N;
• X5, X6 or X7 are independently selected from CH or N;
• R2 and R3 are each independently selected from H, halogen, CH3, and OCH3;
• R4, R5, R6 and R7 are selected from H, halogen, C1-2 alkyl, halomethyl, OH, OCH3, O(CH2)nCH3, OC(CH3)3, OCH(CH3)2, cyclopropyloxy, 5 to 6-membered alkoxy, NH2, N(CH3)2, NH(CH2)nCH3, CN, and N3, wherein n is from 0 to 9;
• B is selected from
• represents a bond connected to ring A;
• represents a bond connected to L;
• and
• L is selected from the group consisting of C1-14 alkyl, C1-14 alkoxy, C2-14 alkenyl, C2-14 alkynyl, C3-10 cycloalkyl, C6-10 aryl or benzyl.