Preparation of 6-substituted menadiones
OwnerElisabeth DAVIOUD-CHARVET, Nathan TROMETER +2inventors
InventorsElisabeth DAVIOUD-CHARVET, Nathan TROMETER, Maxime DONZEL, Matthieu ROIGNANT
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Abstract
A process for the preparation of a compound having the following formula (I): wherein R is selected from the group consisting of: halogen, (C1-C6)alkoxy, (C1-C6)alkyl, halo(C1-C6)alkyl, and halo(C1-C6)alkoxy, said process including a step of intramolecular cyclisation, a step of bromination, a step of aromatization and a step of oxidation.
Claims24
A process for the preparation of a compound having the following formula (I):
- wherein R is selected from the group consisting of:
- halogen, (C1-C6)alkoxy, (C1-C6)alkyl, halo(C1-C6)alkyl, and halo(C1-C6)alkoxy,
- said process comprising the following steps:
- a step of intramolecular cyclisation of a compound having the following formula (II):
- R being as defined above,
- in order to obtain a compound having the following formula (III):
- R being as defined above,
- a step of bromination of the compound having the formula (III), in order to obtain a compound having the following formula (IV):
- R being as defined above,
- a step of aromatization of the compound having the formula (IV), in order to obtain a compound having the following formula (V):
- R being as defined above,
- and
- a step of oxidation of the compound having the formula (V), in order to obtain the compound of formula (I).
The compound having the following formula (I):
- wherein R is selected from the group consisting of:
- Br, halo(C1-C6)alkyl, and halo(C1-C6)alkoxy.
The compound having the following formula (V):
- wherein R is selected from the group consisting of:
- F, Cl, (C1-C6)alkoxy, halo(C1-C6)alkyl, and halo(C1-C6)alkoxy.
The compound having the following formula (IV):
- wherein R is selected from the group consisting of:
- F, Cl, Br, (C1-C6)alkoxy, (C1-C6)alkyl, halo(C1-C6)alkyl, and halo(C1-C6)alkoxy.
The compound having the following formula (III):
- wherein R is selected from the group consisting of:
- F, Cl, halo(C1-C6)alkyl, and halo(C1-C6)alkoxy.
The compound having the following formula (II):
- wherein R is selected from the group consisting of:
- Cl, (C1-C6)alkoxy, halo(C1-C6)alkyl, and halo(C1-C6)alkoxy.
The compound having the following formula (VII):
- wherein R is selected from the group consisting of:
- halo(C1-C6)alkyl, and halo(C1-C6)alkoxy.
A compound selected from the following compounds:
Dependencies are inferred from the claim text.