Novel routes of chemical synthesis of 20s(oh)d3, 20s,25(oh)2d3, 20s,23s(oh)2d3, and 20s,23r(oh)2d3 and their modification of the immune activity of pbmcs
OwnerAndrzej Slominski, Pawel Brzeminski +1inventors
InventorsAndrzej Slominski, Pawel Brzeminski, Adrian Fabisiak
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Abstract
The present disclosure is concerned with methods of making hydroxy derivatives of vitamin D3, compounds useful as intermediates in the preparation of the hydroxy derivatives, and methods of making the intermediates. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
Claims40
A compound having a structure represented by a formula:
- wherein R6 is a C1-C8 alkyl;
- and
- wherein each occurrence of PG is independently a silyl protecting group,
- or a pharmaceutically acceptable salt thereof.
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A method of making a compound having a structure represented by a formula:
- wherein R6 is a C1-C8 alkyl;
- and
- wherein each occurrence of PG is independently a silyl protecting group,
- or a pharmaceutically acceptable salt thereof, the method comprising reacting an aldehyde having a structure represented by a formula:
- or a pharmaceutically acceptable salt thereof, and a Grignard reagent having a structure represented by a formula:
- R6—Mg—X,
- wherein X is a halide.
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A method of making a compound having a structure represented by a formula:
- wherein R6 is a C1-C8 alkyl,
- or a pharmaceutically acceptable salt thereof, the method comprising deprotecting an alcohol having a structure represented by a formula:
- wherein each occurrence of PG is independently a silyl protecting group,
- or a pharmaceutically acceptable salt thereof.
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Dependencies are inferred from the claim text.