Ionizable lipid compound for nucleic acid delivery and lnp composition thereof

A lipid compound having a structure of formula I below;

• wherein,
• at least one of L1 and L2 is —O(C═O)O— or —NRa—, and
• the other one of L1 or L2 is —O—, —O(C═O)O—, —(C═O) NRa—, —NRa(C═O)—, —NRa—, —O(C═O)—, —(C═O)O—, —C(═O)—, —S(O) x-, —S—S—, —C(═O)S—, —SC(═O)—, —NRaC(═O) NRa—, —OC(═O) NRa—, or —NRaC(═O)O—;
• G1 and G2 are each independently unsubstituted C1-C12 alkylene or C1-C12 alkenylene;
• G3 is C1-C24 alkylene, C1-C24 alkenylene, C3-C8 cycloalkylene, or C3-C8 cycloalkenylene;
• Ra is H or C1-C12 hydrocarbyl;
• R1 and R2 are each independently C6-C24 alkyl or C6-C24 alkenyl;
• R3 is H, OH, OR4, CN, —C(═O) OR4, —OC(═O) R4, or —NR5C(═O) R4;
• R4 is C1-C12 hydrocarbyl;
• R5 is H or C1-C6 hydrocarbyl;
• x is 0, 1 or 2.