Compositions and methods targeting filamentous bacteriophage
AssigneesThe University of Montana, Inimmune Corporation
InventorsPatrick Secor, Jay Evans, David Burkhart
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Abstract
Multivalent conjugates and conjugate compositions of peptides derived from the CoaB coat protein of Pseudomonas aeruginosa filamentous (Pf) bacteriophage and conjugates adjuvanted with a TLR 4 and/or TLR 7/8 agonist induce and/or enhance an immune response toward Pseudomonas aeruginosa filamentous (Pf) bacteriophage. The conjugates, compositions, and vaccines have utility to reduce, prevent and/or ameliorate the adverse effect of Pseudomonas aeruginosa infection, such as biofilm formation.
Claims34
An immunogenic composition comprising:
- a first Pf bacteriophage peptide, or derivative thereof;
- a second Pf bacteriophage peptide, or derivative thereof;
- wherein the second Pf bacteriophage peptide, or derivative thereof, is different from the first bacteriophage peptide or derivative thereof;
- and
- one or more carriers;
- wherein the Pf bacteriophage peptides, or derivatives thereof, are independently coupled to the one or more carriers.
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23-24. (canceled)
The immunogenic composition of claim 24, wherein Y is a glycine, alanine, or serine residue or a glycine-serine diamino acid residue.
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The immunogenic composition of claim 51, wherein at least one linker moiety is
- and
- the at least one linker moiety bonds to the linker-binding moiety at the 3-position of the succinimide.
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61-66. (canceled)
Dependencies are inferred from the claim text.