Method of producing and refining carrier-free lutetium-177 using chromatography
AssigneeKorea Atomic Energy Research Institute
InventorsKang Hyuk CHOI, Ul Jae PARK, Jun Sing LEE, A Ran KIM
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Abstract
The present invention relates to a method of producing and refining carrier-free lutetium-177 using chromatography, and more specifically to a method of producing and refining carrier-free lutetium 1-77 using chromatography having excellent resolution of lutetium and ytterbium without a concentration gradient of an eluent.
Claims16
A method for separating carrier-free lutetium-177 (Lu-177), which sequentially performs chromatography for a mixture comprising a compound of ytterbium and lutetium-177 (Lu-177) produced by irradiating neutrons at a compound of ytterbium-176 (Yb-176) as a target by 2 columns below:
- 1) separation column:
- a separation column with a cation exchange resin as a stationary phase, and saturated with a first eluent comprising at least one of primary to quaternary aminium ions and a chelating agent in a column filled with the stationary phase;
- and
- 2) purification column:
- a purification column with the cation exchange resin as a stationary phase, and impregnated with water,
- wherein the first eluent is used as a mobile phase.
Dependencies are inferred from the claim text.