Increased ethanol production by over-expression of kgd2 in yeast
AssigneeDanisco US Inc.
InventorsMin Qi, Yehong Jamie Wang, Quinn Qun Zhu
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Abstract
Described are compositions and methods relating to modified yeast cells that over-express α-ketoglutarate dehydrogenase (K.GD2). Die modified yeast cells produce increased amounts of ethanol compared to otherwise identical parental yeast cells. Such yeast cells are particularly useful for large-scale ethanol production from starch substrates.
Claims19
Modified yeast cells derived from parental yeast cells, the modified cells comprising a genetic alteration that causes the modified cells to produce an increased amount of α-ketoglutarate dehydrogenase (KGD2) polypeptides compared to the parental cells, wherein the modified cells produce during fermentation an increased amount of ethanol compared to the amount of ethanol produced by otherwise identical parental yeast cells.
A method for increased production of alcohol from yeast cells grown on a carbohydrate substrate, comprising:
- introducing into parental yeast cells a genetic alteration that increases the production of KGD2 polypeptides compared to the amount produced in otherwise identical parental cells.
Dependencies are inferred from the claim text.