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US 2024/0318202 A1Published application
Engineered nodaviral cargo delivery systems
AssigneeArizona Board of Regents on Behalf of the University of Arizona
InventorsArun Dhar, Arjoneel Dhar, Rod Russel R. Alenton
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Abstract
Described herein are engineered nodaviral vectors, systems, and uses thereof. In some embodiments, the engineered nodaviral vectors and/or systems can be used to deliver a cargo, such as a nucleic acid cargo, to a cell or cell population, or a subject. In some embodiments, the cargo is a therapeutic or preventative.
Claims45
An engineered cargo delivery system polynucleotide comprising:
- an engineered gamma or beta nodavirus polynucleotide comprising
- a nodavirus capsid polypeptide construct comprising a gamma or beta nodavirus RNA2 encoding polynucleotide or a capsid forming domain thereof operatively coupled to one or more regulatory elements;
- and
- a cargo delivery construct comprising a 5′ untranslated region (UTR) of RNA1 of a native gamma or beta nodavirus, a 3′ UTR of RNA1 of a native gamma or beta nodavirus, or both;
- and a cargo polynucleotide, wherein the cargo polynucleotide is operatively coupled to the 5′ UTR of RNA1 of a native gamma or beta nodavirus, the 3′ UTR of RNA1 of a native gamma or beta nodavirus, or both, and wherein the cargo polynucleotide is operatively coupled to one or more regulatory elements.
2 more elements
Dependencies are inferred from the claim text.