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US 2024/0318160 A1Published application
Two combined mutations that introduce the second entry pathway to synthesized lignin from tyrosine in plants
AssigneeWisconsin Alumni Research Foundation
InventorsHiroshi Maeda, Yuri Takeda-Kimura, Bethany Moore
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Abstract
The present invention provides engineered phenylalanine ammonia-lyase (PAL) enzymes comprising one or more mutations that increase the enzymes' tyrosine ammonia-lyase (TAL) activity. Also provided are plants comprising the engineered PAL enzymes and methods of using these plants to sequester CO2 or produce phenylpropanoid-derived products.
Claims22
An engineered phenylalanine ammonia-lyase (PAL) enzyme comprising a mutation relative to a wild-type PAL enzyme, wherein the mutation is at a position corresponding to residue 112 of SEQ ID NO:
- 28, and wherein the engineered PAL enzyme has increased TAL activity relative to the wild-type PAL enzyme.
Dependencies are inferred from the claim text.