Cyclic dinucleotide metal compound, and preparation and application thereof
AssigneeHangzhou Xingao Biotechnology Co., Ltd
InventorsXiangshi TAN, Daofeng XIANG, Yingxuan TAN
Life of this patent
Estimating the term…
Abstract
A cyclic dinucleotide metal compound, and a preparation thereof are provided. The cyclic dinucleotide metal compound is represented by [M(cyclic dinucleotide)] or [M′2(cyclic dinucleotide)], where M is Mg2+, Zn2+, Mn2+ or Fe2+, and M′ is Li+. The cyclic dinucleotide is 2′3′-cGAMP, c-di-AMP, c-di-GMP, c-di-IMP, c-GMP-IMP or a derivative thereof. Applications of the cyclic dinucleotide metal compound in the treatment of neurodegenerative diseases, ischemic cerebrovascular injuries and tumors are also provided.
Claims16
A cyclic dinucleotide metal compound, wherein the cyclic dinucleotide metal compound is represented by [M(cyclic dinucleotide)];
- wherein Mis Mg2+, Zn2+, Mn2+ or Fe2+;
- and the cyclic dinucleotide is 2′3′-cGAMP, c-di-AMP, c-di-GMP, c-di-IMP, c-GMP-IMP or a derivative thereof.
A cyclic dinucleotide metal compound, wherein the cyclic dinucleotide metal compound is represented by [M′2(cyclic dinucleotide)];
- wherein M′ is Li+;
- and the cyclic dinucleotide is 2′3′-cGAMP, c-di-AMP, c-di-GMP, c-di-IMP, c-GMP-IMP or a derivative thereof.
Dependencies are inferred from the claim text.