Marker for lymphocytic adenohypophysitis and related diseases, and use of the marker
AssigneesFujita Academy, National University Corporation Tokai National Higher Education and Research System
InventorsYoshihisa SUGIMURA, Atsushi SUZUKI, Haruki FUJISAWA, Naoko IWATA, Takashi WATANABE, Kozo KAIBUCHI, Tomoki NISHIOKA
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Abstract
The purpose of the present disclosure is to provide a technique that can contribute to less invasive or more reliable diagnosis of lymphocytic anterior hypophysitis and its related diseases. For this purpose, the KCNMA1 (calcium-activated potassium channel subunit alpha-1) protein or an epitope thereof is used as a diagnostic agent for lymphocytic anterior hypophysitis.
Claims9
1-17. (canceled)
A method, comprising:
- detecting one or two or more antibodies selected from the group consisting of anti-KCNMA1 antibody, anti-GIT2 antibody, anti-FRAT1 antibody, anti-SLC1A5 antibody, anti-INADL antibody, anti-DOC2B antibody, anti-GATA2 antibody, anti-ZP1 antibody, and anti-PTPN13 antibody, in a sample obtained from an individual, and
- providing information regarding possibility of at least one disease morbidity of the individual, wherein the at least one disease comprises autoimmune hypothalamic hypophysitis and related diseases.
A method, comprising:
- detecting one or two or more antibodies selected from the group consisting of anti-KCNMA1 antibody, anti-GIT2 antibody, anti-FRAT1 antibody, anti-SLC1A5 antibody, anti-INADL antibody, anti-DOC2B antibody, anti-GATA2 antibody, anti-ZP1 antibody, and anti-PTPN13 antibody, in a sample obtained from an individual, and
- providing information regarding possibility of lymphocytic hypophysitis morbidity of the individual.
A kit for possibility of at least one disease morbidity, comprising:
- one or two or more proteins or epitopes that immunologically bind to one or two or more antibodies selected from the group consisting of anti-KCNMA1 antibody, anti-GIT2 antibody, anti-FRAT1 antibody, anti-SLC1A5 antibody, anti-INADL antibody, anti-DOC2B antibody, anti-GATA2 antibody, anti-ZP1 antibody, and anti-PTPN13 antibody,
- wherein the at least one disease comprises autoimmune hypothalamic hypophysitis and related diseases.
Dependencies are inferred from the claim text.