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US 2024/0309000 A1Published application
Process for Preparing an FGFR Inhibitor
AssigneePrincipia Biopharma Inc.
InventorsJian Zhu, Mohammad R. Masjedizadeh
Life of this patent
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Abstract
Disclosed herein are processes for preparing 8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-(methylamino)pyrido[2,3-d]pyrimidin-7(8H)-one and FGFR inhibitor, as well as polymorphs and/or salt forms thereof.
Claims22
1-38. (canceled)
A process of preparing a compound of formula (I):
- comprising:
- reacting a compound of formula (5):
- or a salt thereof with a compound (iii) wherein LG is a leaving group
A process for preparing a compound of formula (2) and/or formula (3), comprising reacting a compound of formula (1):
- or a salt thereof, with a N-chlorosuccinimide to provide a compound of formula (2) and/or (3):
- where each PG is an amino protecting group.
A process for preparing a compound of formula (4), comprising treating a compound of formula (2) or (3):
- with methylamine to give a compound of formula (4)
- wherein each PG is an amino protecting group.
Dependencies are inferred from the claim text.