Estrogen receptor-modulating compounds

A compound of formula II′

• wherein:
• each Ra is independently selected from H, C1-C3 alkyl, phenyl (optionally substituted with 1-3 groups selected from fluorine, chlorine, C1-C3 alkyl, CN, OC1-C3 alkyl, OH), OH, OC1-3alkyl, CN, fluorine, chlorine, O(CO)R, O(CO)NR1R2, OPO3, OSO3, O(SO2)NR1R2, or two adjacent Ra together form:
• R is C1-C6 alkyl or aryl;
• R1 and R2 are each independently hydrogen or C1-C6 alkyl;
• each R3 is independently hydrogen;
• C1-C12 acyl or C1-C12 acyloxy;
• each R4 is independently hydrogen, C1-C3 alkyl, fluorine or chlorine;
• each Re is independently selected from hydrogen, halogen, OH, O(CO)R, O(CO)NR1R2, OPO3, OSO3, O(SO2)NR1R2, or wherein two adjacent Re together form:
• each Rf is independently H, C1-C3 alkyl, OC1-C3 alkyl, fluorine or chlorine;
• Rg is hydrogen, C1-C3 alkyl, C1-C3 fluoroalkyl, CN, fluorine, chlorine or bromine;
• X is CH2 or a bond;
• Y is N, and Z is selected from CRf or N;
• U and V are each independently selected from CRa or N;
• and
• W is —CHR′—CHR′—NH—C1-C4alkyl, —CHR′—CHR′—NH—C1-C4fluoroalkyl, —CHR′—CHR′—NH—C3-C6cycloalkyl, —CHR′—CHR′—NH—C1-C4alkyl-C3-C6cycloalkyl,
• wherein each R′ is independently H or C1-C3alkyl;
• or a pharmaceutically acceptable salt thereof.

A compound selected from:

• 1-(4-(2-((Cyclopropylmethyl)amino)ethyl)benzyl)-2-(4-methoxyphenyl)-3-methyl-1H-indol-5-ol;
• 1-(4-(2-((Cyclopropylmethyl)amino)ethyl)benzyl)-3-fluoro-2-(o-tolyl)-1H-indol-5-ol;
• and
• 2-Fluoro-N-(4-((8-fluoro-7-(o-tolyl)pyrrolo[3,2-e]indazol-6(3H)yl)methyl)phenethyl)ethan-1-amine.