Phenyl urea derivative
AssigneeSumitomo Pharma Co., Ltd.
InventorsMasafumi KOMIYA, Shunichiro UESUGI, Eiji IDEUE, Shoukou LEE, Daisuke TANAKA, Yuta FUNAKOSHI
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Abstract
The present invention relates to a medicament for treating or preventing a disease related to orexin receptor, especially orexin receptor type 2, comprising a new compound having a urea structure or a pharmaceutically acceptable salt thereof as an active ingredient. In more detail, the present invention relates to a medicament for treating or preventing a disease such as narcolepsy, idiopathic hypersomnia, hypersomnia, sleep apnea syndrome.
Claims35
A compound of formula (1):
- or a pharmaceutically acceptable salt thereof,
- wherein
- R1 is optionally-substituted C6-10 aromatic carbocyclyl group, optionally-substituted 5- to 10-membered aromatic heterocyclyl group, optionally-substituted C3-6 saturated carbocyclyl group, optionally-substituted 4- to 10-membered saturated heterocyclyl group, or cyano;
- L1 and L2 are each independently single bond, methylene (which may be optionally substituted with the same or different one or more C1-6 alkyl groups), —NR6—, —C(═O)—, —OC(═O)—, —SO—, —SO2—, —S—, or oxygen atom;
- R2 is hydrogen atom, hydroxy group, halogen atom, cyano, optionally-substituted C1-6 alkyl, optionally-substituted C1-6 alkoxy, C(═O)NR3R4 or C(═O)O—R5;
- R3, R4, R5 and R6 are each independently hydrogen atom or optionally-substituted C1-6 alkyl;
- ring E is optionally-substituted 5- to 10-membered aromatic heterocyclyl group or optionally-substituted 4- to 10-membered saturated heterocyclyl group;
- ring G is optionally-substituted C6-10 aromatic carbocyclyl group, optionally-substituted 5- to 10-membered aromatic heterocyclyl group, optionally-substituted C3-6 saturated carbocyclyl group, or optionally-substituted 4- to 10-membered saturated heterocyclyl group;
- and
- A is oxygen atom or sulfur atom.
The compound according to any one of Items 1 to 19 or a pharmaceutically acceptable salt thereof, wherein ring G is the following formula (1b-3):
- wherein
- Rb3 is C1-6 alkyl (which may be optionally substituted with the same or different one or more substituents selected from halogen atom or C1-6 alkoxy, 5- to 10-membered aromatic heterocyclyl group (which may be optionally substituted with the same or different one or more substituents selected from halogen atom, C1-6 alkyl or C1-6 alkoxy), or C3-7 cycloalkyl (which may be optionally substituted with the same or different one or more substituents selected from halogen atom, C1-6 alkyl or C1-6 alkoxy).
Dependencies are inferred from the claim text.