Virus filtration operations employing an oversized virus prefilter
AssigneeAmgen Inc.
InventorsAndrew John Maloney, David George Meliek, Joseph Edward Basconi, Sravanthi Vadlamannati, Glen Bolton
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Abstract
Disclosed herein are methods for removing at least one viral contaminant from a concentrated composition, comprising filtering the concentrated composition through a virus prefilter and a virus filter over one or more filtration cycles, wherein a ratio of the virus prefilter area to the virus filter area in each filtration cycle is at least about 2:1, as well as viral filtration skids for use in such methods.
Claims20
A method of removing at least one viral contaminant from a composition, comprising filtering the composition through a virus prefilter and a virus filter, wherein:
- the virus filter is loaded to at least about 1500 L/m2 over one or more filtration cycles;
- and
- a ratio of the virus prefilter area to the virus filter area in each filtration cycle is at least about 2:1.
A method of removing at least one viral contaminant from a composition, comprising filtering the composition through a virus prefilter and a virus filter over at least two filtration cycles, wherein:
- the virus prefilter is replaced after each filtration cycle;
- the virus filter is loaded to at least about 1500 L/m2 over the at least two filtration cycles;
- and
- a ratio of the virus prefilter area to the virus filter area in each filtration cycle is at least about 2:1.
Dependencies are inferred from the claim text.