Arginine methyltransferase inhibitor and use thereof

A compound shown in formula (I), or a pharmaceutically acceptable salt thereof, or a deuterated compound thereof:

• X1, X2, X3 and X4 are each independently selected from the group consisting of:
• CR, NR and N;
• the dash line is a chemical bond or absent;
• ring A is selected from the group consisting of substituted or unsubstituted saturated or partially unsaturated (non-aromatic) 4-8 membered carbocycle, and substituted or unsubstituted saturated or partially unsaturated (non-aromatic) 4-8 membered heterocycle;
• ring B is selected from the group consisting of H, halogen, cyano, amino, nitro, hydroxyl, thiol, aldehyde group, carboxyl, sulfonyl, substituted or unsubstituted C1-C6alkyl, substituted or unsubstituted C1-C6alkoxy, substituted or unsubstituted C6-C10aryl, substituted or unsubstituted 5-12 membered heteroaromatic ring, substituted or unsubstituted 3-12 membered heterocycle containing 1-3 heteroatoms selected from oxygen, sulfur and nitrogen, substituted or unsubstituted —C1-C6alkyl-6-10 membered aryl, substituted or unsubstituted C3-C12carbocycle, substituted or unsubstituted C2-C10acyl, substituted or unsubstituted C2-C10ester group, substituted or unsubstituted C6-C10aryloxy, substituted or unsubstituted C1-C6 amide, substituted or unsubstituted C1-C4 alkyl-S(O)2, and substituted or unsubstituted C1-C4alkyl-SO—;
• m and n are each independently selected from the group consisting of 0, 1, 2, 3, 4, 5 and 6;
• L is selected from the group consisting of chemical bonds, —O—, —(CHR6)p—, —CHR6—O—, —CHR6—C(O)—, carbonyl, S, —NH—, —NHC(O)—, —NHS(O)2—, —NHC(O)NH—, —NHC(S)NH—, —COO—, —O—S(O)2—, —COO—CH2—, —C(O)CH2—, and —S(O)2—, or L is absent;
• p is selected from the group consisting of 1, 2 and 3;
• R1 and R2 are each independently selected from the group consisting of H, substituted or unsubstituted C1-C6 alkyl, and substituted or unsubstituted C3-C6cycloalkyl;
• R3 is a group selected from the group consisting of H, halogen, cyano, amino, nitro, hydroxyl, thiol, aldehyde group, carboxyl, sulfonyl, substituted or unsubstituted C1-C6alkyl, substituted or unsubstituted C2-C6alkenyl, substituted or unsubstituted C1-C6alkoxy, substituted or unsubstituted C1-C6alkylamino, substituted or unsubstituted C6-C10aryl, substituted or unsubstituted 5-12 membered heteroaryl, substituted or unsubstituted 5-7 membered heterocycle containing 1-3 heteroatoms selected from oxygen, sulfur and nitrogen, substituted or unsubstituted —C1-C6alkyl-phenyl, substituted or unsubstituted C3-C12carbocycle, substituted or unsubstituted C2-C10acyl, substituted or unsubstituted C2-C10ester group, substituted or unsubstituted C6-C10aryloxy, substituted or unsubstituted C1-C6 amide, substituted or unsubstituted C1-C4alkyl-S(O)2—, and substituted or unsubstituted C1-C4alkyl-SO—;
• R is a group selected from the group consisting of H, halogen, cyano, amino, nitro, hydroxyl, thiol, aldehyde group, carboxyl, sulfonyl, substituted or unsubstituted C1-C6alkyl, substituted or unsubstituted C1-C6alkoxy, substituted or unsubstituted C1-C6alkylamino, substituted or unsubstituted C6-C10aryl, substituted or unsubstituted 5-12 membered heteroaryl, substituted or unsubstituted 4-7 membered heterocycle containing 1-3 heteroatoms selected from oxygen, sulfur and nitrogen, substituted or unsubstituted —C1-C6alkyl-phenyl, substituted or unsubstituted C3-C12carbocycle, substituted or unsubstituted C2-C10acyl, substituted or unsubstituted C2-C10ester group, substituted or unsubstituted C6-C10aryloxy, substituted or unsubstituted C1-C6 amide, substituted or unsubstituted C1-C4alkyl-S(O)2—, and substituted or unsubstituted C1-C4alkyl-SO—;
• or two R located on adjacent ring atoms together with the ring atoms to which they are attached form a substituted or unsubstituted 5-11 membered carbocycle or heterocycle, and the ring is partially unsaturated or saturated;
• preferably, the carbocycle or heterocycle is a 5-9 membered carbocycle or heterocycle, more preferably a 5-7 membered carbocycle or heterocycle (the carbocycle or heterocycle is saturated, partially unsaturated or aromatic);
• R4 is a group selected from the group consisting of H, halogen, cyano, amino, nitro, hydroxyl, thiol, aldehyde group, carboxyl, sulfonyl, substituted or unsubstituted C1-C6alkyl, substituted or unsubstituted C2-C6alkenyl, substituted or unsubstituted C1-C6alkoxy, substituted or unsubstituted C1-C6alkylamino, substituted or unsubstituted C6-C10aryl, substituted or unsubstituted 5-12 membered heteroaryl, substituted or unsubstituted 5-7 membered heterocycle containing 1-3 heteroatoms selected from oxygen, sulfur and nitrogen, substituted or unsubstituted —C1-C6alkyl-phenyl, substituted or unsubstituted C3-C12carbocycle, substituted or unsubstituted C2-C10acyl, substituted or unsubstituted C2-C10ester group, substituted or unsubstituted C6-C10aryloxy, substituted or unsubstituted C1-C6 amide, substituted or unsubstituted C1-C4alkyl-S(O)2—, and substituted or unsubstituted C1-C4alkyl-SO—;
• or two R4 on the same or adjacent ring atoms together with the ring atoms to which they attached form a substituted or unsubstituted 3-11 membered carbocycle or heterocycle, and the ring is a partially unsaturated ring, saturated ring or aromatic ring;
• R6 is a group selected from the group consisting of H, halogen, cyano, amino, nitro, hydroxyl, thiol, aldehyde group, carboxyl, acyl, sulfonyl, substituted or unsubstituted C1-C6alkyl, substituted or unsubstituted C1-C6alkoxy, and substituted or unsubstituted C1-C6alkylamino;
• unless otherwise specified, in the above formulas, the “substituted” means that the hydrogen atom on the corresponding group is substituted by one or more substituents selected from the group consisting of:
• deuterium, tritium, halogen, hydroxyl, carboxyl, thiol, benzyl, oxo (=O), C1-C12alkoxycarbonyl, C1-C6aldehyde group, amino, C1-C6 amide, nitro, cyano, unsubstituted or halogenated C1-C6alkyl, C2-C10alkenyl, C1-C6alkoxy, C1-C6alkyl-amino, C1-C6alkyl-sulfonamide, C1-C6alkyl-ureido, C1-C6alkyl-S—, C6-C10aryl, five- or six-membered heteroaryl, five- or six-membered non-aromatic heterocyclyl, five- or six-membered non-aromatic heterocyclyl-(CH2)—, —O—(C6-C10aryl), —O-(five or six membered heteroaryl), —NH—(C6-C10aryl), —NH-(five-membered or six-membered heteroaryl), C1-C12alkylaminocarbonyl, unsubstituted or halogenated C2-C10acyl, sulfonyl (—SO2—OH), sulfonamide (—SO2-NH2), phosphoryl (—PO3—OH), unsubstituted or halogenated C1-C4alkyl-S(O)2—, unsubstituted or halogenated C1-C4alkyl-SO—,
• in each formula, the heterocycle or heteroaromatic ring has 1-3 heteroatoms selected from the group consisting of N, S and O;
• each aryl, heteroaryl, and heterocyclyl can be independently substituted by 1-3 substituents selected from the group consisting of deuterium, tritium, halogen, hydroxyl, carboxyl, thiol, C1-C6alkyl, and C1-C6alkoxy.