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US 2024/0306933 A1Published application
DYNAMIC 129Xe GAS EXCHANGE SPECTROSCOPY
AssigneeDuke University
InventorsElianna Bier, Bastiaan Driehuys, Ziyi Wang, Sudarshan Rajagopal
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Abstract
Methods and systems with 129Xe dynamic spectroscopy with a fitting function that includes one or more non-Lorentzians, optionally with a barrier Voigt, and signal processing for identifying cardiogenic oscillations for evaluating disease states, use in drug discovery or monitoring disease status.
Claims16
A method of identifying a cardiopulmonary disease of a patient, comprising:
- obtaining a plurality of 129Xe imaging parameters of at least one lung of the patient including red blood cell (RBC) defect percentage, ventilation defect percentage and barrier defect percentage;
- obtaining a plurality of 129Xe spectroscopy parameters of the at least one lung of the patient including RBC chemical shift oscillation and RBC amplitude oscillation;
- and
- identifying whether the patient has a cardiopulmonary disease based on the obtained 129Xe imaging parameters and the 129Xe dynamic spectroscopy parameters.
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